Drug Information
Drug General Information | |||||
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Drug ID |
D0M4HC
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Former ID |
DIB012626
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Drug Name |
L-757464
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Synonyms |
5-Chloro-2-[4-[4-(2-oxo-2,3-dihydrobenzoxazol-3-yl)piperidin-1-yl]butyl]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
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Indication | Prostate hyperplasia [ICD10:N40] | Terminated | [1] | ||
Company |
Merck & Co Inc
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Structure |
Download2D MOL |
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Canonical SMILES |
S1(=O)(=O)N(C(=O)c2c1ccc(c2)Cl)CCCCN1CCC(n2c(=O)oc3c2cc<br />cc3)CC1
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CAS Number |
CAS 173842-04-1
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Target and Pathway | |||||
Target(s) | Alpha-1A adrenergic receptor | Target Info | Antagonist | [2] | |
KEGG Pathway | Calcium signaling pathway | ||||
cGMP-PKG signaling pathway | |||||
Neuroactive ligand-receptor interaction | |||||
AMPK signaling pathway | |||||
Adrenergic signaling in cardiomyocytes | |||||
Vascular smooth muscle contraction | |||||
Salivary secretion | |||||
PANTHER Pathway | Alpha adrenergic receptor signaling pathway | ||||
Reactome | Adrenoceptors | ||||
G alpha (q) signalling events | |||||
G alpha (12/13) signalling events | |||||
WikiPathways | Monoamine GPCRs | ||||
Calcium Regulation in the Cardiac Cell | |||||
GPCRs, Class A Rhodopsin-like | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
Endothelin Pathways | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
AMPK Signaling | |||||
References | |||||
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010051) | ||||
REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010051) | ||||
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