Drug General Information
Drug ID	D0M7AX
Former ID	DNC011886
Drug Name	3-Isopropyl-1-methyl-3,7-dihydro-purine-2,6-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533486]
Structure		Download 2D MOL 3D MOL
Formula	C9H12N4O2
Canonical SMILES	CC(C)N1C2=C(C(=O)N(C1=O)C)NC=N2
InChI	1S/C9H12N4O2/c1-5(2)13-7-6(10-4-11-7)8(14)12(3)9(13)15/h4-5H,1-3H3,(H,10,11)
InChIKey	ZBQTVZYXBOKEMJ-UHFFFAOYSA-N
PubChem Compound ID	10219934
Target and Pathway
Target(s)	Adenosine A2a receptor	Target Info	Inhibitor	[533486]
KEGG Pathway	Rap1 signaling pathway
	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
	Parkinson's disease
	Alcoholism
Pathway Interaction Database	HIF-2-alpha transcription factor network
PathWhiz Pathway	Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome	NGF-independant TRKA activation
	Adenosine P1 receptors
	G alpha (s) signalling events
	Surfactant metabolism
WikiPathways	Nucleotide GPCRs
	Monoamine Transport
	GPCRs, Class A Rhodopsin-like
	NGF signalling via TRKA from the plasma membrane
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 533486	J Med Chem. 1986 Jul;29(7):1305-8.Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors.
Ref 533486	J Med Chem. 1986 Jul;29(7):1305-8.Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors.

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