Drug Information
Drug General Information | |||||
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Drug ID |
D0M8OC
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Former ID |
DNCL003065
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Drug Name |
Bavisant
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Synonyms |
JNJ-31001074
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Drug Type |
Small molecular drug
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Indication | Attention deficit hyperactivity disorder [ICD9: 314; ICD10:F90] | Phase 2 | [1] | ||
Company |
Johnson & Johnson Pharmaceutical Research & Development
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Structure |
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Download2D MOL |
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Formula |
C19H27N3O2
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Canonical SMILES |
C1CC1N2CCN(CC2)C(=O)C3=CC=C(C=C3)CN4CCOCC4
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InChI |
1S/C19H27N3O2/c23-19(22-9-7-21(8-10-22)18-5-6-18)17-3-1-16(2-4-17)15-20-11-13-24-14-12-20/h1-4,18H,5-15H2
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InChIKey |
BGBVSGSIXIIREO-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Histamine H3 receptor | Target Info | Antagonist | [2] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
Reactome | Histamine receptors | ||||
G alpha (i) signalling events | |||||
WikiPathways | Monoamine Transport | ||||
GPCRs, Class A Rhodopsin-like | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
References | |||||
REF 1 | ClinicalTrials.gov (NCT00566449) A Safety and Effectiveness Study of JNJ-31001074 in Adults With Attention-Deficit/Hyperactivity Disorder.. U.S. National Institutes of Health. | ||||
REF 2 | Randomized clinical study of a histamine H3 receptor antagonist for the treatment of adults with attention-deficit hyperactivity disorder. CNS Drugs. 2012 May 1;26(5):421-34. | ||||
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