Drug Information

Drug General Information
Drug ID
D0M9VE
Former ID
DIB001574
Drug Name
EXISULIND
Synonyms
Aposulind; Aptosyn; Sulindac sulfone; FGN-1; Prevatac (former Brand Name); Exisulind < Prop INN >; (Z)-5-Fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-indene-3-acetic acid
Drug Type
Small molecular drug
Indication Colorectal cancer [ICD9: 153, 154; ICD10:C18-C21] Phase 3 [521600]
Company
OSI Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C20H17FO4S
Canonical SMILES
CC1=C(CC(=O)O)c2cc(F)ccc2/C/1=C\\c3ccc(cc3)S(=O)(=O)C
InChI
1S/C20H17FO4S/c1-12-17(9-13-3-6-15(7-4-13)26(2,24)25)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-
InChIKey
MVGSNCBCUWPVDA-MFOYZWKCSA-N
CAS Number
CAS 59973-80-7
PubChem Compound ID
5472495
Target and Pathway
Target(s) CGMP-specific 3',5'-cyclic phosphodiesterase Target Info Modulator [525834]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Reactome cGMP effects
References
Ref 521600ClinicalTrials.gov (NCT00085826) A Phase III Study of the Efficacy of Taxotere/Aptosyn Versus Taxotere/Placebo in Non-Small Cell Lung Cancer Patients. U.S. National Institutes of Health.
Ref 525834Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin. Cancer Res. 2000 Jul 1;60(13):3338-42.

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