Drug General Information |
Drug ID |
D0MC0O
|
Former ID |
DIB011522
|
Drug Name |
AZD-1080
|
Drug Type |
Small molecular drug
|
Indication |
Alzheimer disease [ICD9: 331; ICD10:G30]
|
Discontinued in Phase 1 |
[1],
[2]
|
Company |
AstraZeneca plc
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C19H18N4O2
|
InChI |
InChI=1S/C19H18N4O2/c20-10-13-1-3-16-15(9-13)18(19(24)22-16)17-4-2-14(11-21-17)12-23-5-7-25-8-6-23/h1-4,9,11,21H,5-8,12H2,(H,22,24)/b18-17+
|
InChIKey |
JULOXTBHCHEFBE-ISLYRVAYSA-N
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PubChem Compound ID |
|
PubChem Substance ID |
30544362, 57292587, 189294381, 196362764, 223366150, 223386800, 242060352, 249775809, 251910744, 252160791, 252553595
|
Target and Pathway |
Target(s) |
Glycogen synthase kinase-3 beta |
Target Info |
Modulator |
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KEGG Pathway
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ErbB signaling pathway
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Chemokine signaling pathway
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Cell cycle
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PI3K-Akt signaling pathway
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Wnt signaling pathway
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Hedgehog signaling pathway
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Axon guidance
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Hippo signaling pathway
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Focal adhesion
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Signaling pathways regulating pluripotency of stem cells
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T cell receptor signaling pathway
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B cell receptor signaling pathway
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Neurotrophin signaling pathway
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Dopaminergic synapse
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Insulin signaling pathway
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Melanogenesis
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Prolactin signaling pathway
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Thyroid hormone signaling pathway
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Non-alcoholic fatty liver disease (NAFLD)
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Alzheimer's disease
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Hepatitis C
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Measles
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Influenza A
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HTLV-I infection
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Epstein-Barr virus infection
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Pathways in cancer
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Colorectal cancer
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Endometrial cancer
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Prostate cancer
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Basal cell carcinoma
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PANTHER Pathway
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Alzheimer disease-presenilin pathway
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Angiogenesis
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Cadherin signaling pathway
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Hedgehog signaling pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Insulin/IGF pathway-protein kinase B signaling cascade
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Interleukin signaling pathway
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PDGF signaling pathway
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PI3 kinase pathway
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Wnt signaling pathway
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Ras Pathway
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CCKR signaling map ST
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Pathway Interaction Database
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LPA receptor mediated events
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Degradation of beta catenin
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Reelin signaling pathway
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Presenilin action in Notch and Wnt signaling
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Integrin-linked kinase signaling
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CDC42 signaling events
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LKB1 signaling events
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Canonical Wnt signaling pathway
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Glucocorticoid receptor regulatory network
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C-MYC pathway
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Regulation of Androgen receptor activity
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BMP receptor signaling
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Hedgehog signaling events mediated by Gli proteins
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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Validated transcriptional targets of deltaNp63 isoforms
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Aurora A signaling
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Insulin-mediated glucose transport
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Class I PI3K signaling events mediated by Akt
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p53 pathway
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Trk receptor signaling mediated by PI3K and PLC-gamma
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Reactome
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Degradation of beta-catenin by the destruction complex
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AKT phosphorylates targets in the cytosol
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Regulation of HSF1-mediated heat shock response
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CRMPs in Sema3A signaling
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Disassembly of the destruction complex and recruitment of AXIN to the membrane
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S33 mutants of beta-catenin aren't phosphorylated
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S37 mutants of beta-catenin aren't phosphorylated
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S45 mutants of beta-catenin aren't phosphorylated
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T41 mutants of beta-catenin aren't phosphorylated
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Degradation of GLI2 by the proteasome
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Constitutive Signaling by AKT1 E17K in Cancer
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WikiPathways
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DNA Damage Response (only ATM dependent)
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Senescence and Autophagy in Cancer
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Notch Signaling Pathway
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Glycogen Metabolism
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Insulin Signaling
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Wnt Signaling Pathway
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Wnt Signaling Pathway and Pluripotency
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IL-6 signaling pathway
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Wnt Signaling Pathway Netpath
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Copper homeostasis
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Focal Adhesion
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Hair Follicle Development: Induction (Part 1 of 3)
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Cardiac Hypertrophic Response
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Degradation of beta-catenin by the destruction complex
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T-Cell Receptor and Co-stimulatory Signaling
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Cardiac Progenitor Differentiation
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BDNF signaling pathway
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Corticotropin-releasing hormone
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B Cell Receptor Signaling Pathway
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IL17 signaling pathway
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Neural Crest Differentiation
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Alzheimers Disease
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IL-7 Signaling Pathway
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Regulation of Microtubule Cytoskeleton
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TWEAK Signaling Pathway
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Leptin signaling pathway
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Semaphorin interactions
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Cell Cycle
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MicroRNAs in cardiomyocyte hypertrophy
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Androgen receptor signaling pathway
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IL-5 Signaling Pathway
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References |
REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7819). |
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REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021264) |