Drug Information

Drug General Information
Drug ID
D0MC3R
Former ID
DIB014796
Drug Name
Goxalapladib
Synonyms
Goxalapladib < USAN; Prop INN >; 2-[2-[2-(2,3-Difluorophenyl)ethyl]-4-oxo-1,4-dihydro-1,8-naphthyridin-1-yl]-N-[1-(2-methoxyethyl)piperidin-4-yl]-N-[4'-(trifluoromethyl)biphenyl-4-ylmethyl]acetamide; 677116
Drug Type
Small molecular drug
Indication Arteriosclerosis [ICD9: 440; ICD10:I70] Discontinued in Phase 1 [547940]
Structure
Download
2D MOL

3D MOL
Formula
C40H39F5N4O3
Canonical SMILES
COCCN1CCC(CC1)N(Cc2ccc(cc2)c3ccc(cc3)C(F)(F)F)C(=O)CN4C<br />(=CC(=O)c5cccnc45)CCc6cccc(F)c6F
InChI
1S/C40H39F5N4O3/c1-52-23-22-47-20-17-32(18-21-47)48(25-27-7-9-28(10-8-27)29-11-14-31(15-12-29)40(43,44)45)37(51)26-49-33(16-13-30-4-2-6-35(41)38(30)42)24-36(50)34-5-3-19-46-39(34)49/h2-12,14-15,19,24,32H,13,16-18,20-23,25-26H2,1H3
InChIKey
OBJKLVFDRLAGJI-UHFFFAOYSA-N
PubChem Compound ID
11686305
Target and Pathway
Target(s) Lipoprotein-associated phospholipase A2 Target Info Modulator [547941]
KEGG Pathway Ether lipid metabolism
Metabolic pathways
Biosynthesis of antibiotics
Pathway Interaction Database Lissencephaly gene (LIS1) in neuronal migration and development
WikiPathways IL1 and megakaryotyces in obesity
Synthesis, Secretion, and Deacylation of Ghrelin
References
Ref 547940Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020582)
Ref 547941Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020582)

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