| Drug General Information |
| Drug ID |
D0MH0S
|
| Former ID |
DNC012469
|
| Drug Name |
1-(3-Fluoro-pyridin-2-yl)-4-methyl-piperazine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C10H14FN3
|
| Canonical SMILES |
CN1CCN(CC1)C2=C(C=CC=N2)F
|
| InChI |
1S/C10H14FN3/c1-13-5-7-14(8-6-13)10-9(11)3-2-4-12-10/h2-4H,5-8H2,1H3
|
| InChIKey |
KZNJAAWCEFRAPW-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Alpha-2A adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Alpha-2B adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
| Alpha-1D adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
| Alpha-1A adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
cGMP-PKG signaling pathway
|
|
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
|
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Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
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Neuroactive ligand-receptor interaction
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Adrenergic signaling in cardiomyocytes
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Vascular smooth muscle contraction
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Salivary secretionhsa04020:Calcium signaling pathway
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AMPK signaling pathway
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Salivary secretion
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NetPath Pathway
|
IL2 Signaling Pathway
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PANTHER Pathway
|
Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
|
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
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Reactome
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Adrenoceptors
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Adrenaline signalling through Alpha-2 adrenergic receptor
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Adrenaline,noradrenaline inhibits insulin secretion
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G alpha (i) signalling events
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G alpha (z) signalling events
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Surfactant metabolismR-HSA-390696:Adrenoceptors
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G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
|
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G alpha (q) signalling events
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G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
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G alpha (12/13) signalling events
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WikiPathways
|
Monoamine GPCRs
|
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GPCRs, Class A Rhodopsin-like
|
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Platelet Aggregation (Plug Formation)
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Integration of energy metabolism
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GPCR ligand binding
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GPCR downstream signalingWP58:Monoamine GPCRs
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Calcium Regulation in the Cardiac Cell
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Gastrin-CREB signalling pathway via PKC and MAPK
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GPCR downstream signaling
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GPCRs, OtherWP58:Monoamine GPCRs
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Endothelin Pathways
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AMPK Signaling
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| References |
| REF 1 | J Med Chem. 1984 Sep;27(9):1182-5.Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines. |
|---|
