Drug General Information
Drug ID	D0MW7H
Former ID	DNC000455
Drug Name	CMI-1145
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[535589]
Structure		Download 2D MOL 3D MOL
Formula	C8H12N4O
Canonical SMILES	C1CC2C(CC1N2)C3=NC(=NO3)N
InChI	1S/C8H12N4O/c9-8-11-7(13-12-8)5-3-4-1-2-6(5)10-4/h4-6,10H,1-3H2,(H2,9,12)
InChIKey	XODBGPCGVOHHEP-UHFFFAOYSA-N
PubChem Compound ID	56603760
PubChem Substance ID	134339876, 151001043
Target and Pathway
Target(s)	Muscarinic acetylcholine receptor M2	Target Info	Agonist	[535589]
	Muscarinic acetylcholine receptor M4	Target Info	Agonist	[535589]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	PI3K-Akt signaling pathway
	Cholinergic synapse
	Regulation of actin cytoskeletonhsa04080:Neuroactive ligand-receptor interaction
	Regulation of actin cytoskeleton
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathway
PathWhiz Pathway	Muscle/Heart Contraction
Reactome	Muscarinic acetylcholine receptors
	G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
	G alpha (i) signalling events
WikiPathways	SIDS Susceptibility Pathways
	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, OtherWP58:Monoamine GPCRs
References
Ref 535589	Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice. Mol Pharmacol. 2002 Nov;62(5):1084-93.
Ref 535589	Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice. Mol Pharmacol. 2002 Nov;62(5):1084-93.

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