Drug Information
Drug General Information | |||||
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Drug ID |
D0N0PU
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Former ID |
DCL000155
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Drug Name |
LTB 019
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Drug Type |
Small molecular drug
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Indication | Asthma [ICD10:J45] | Discontinued in Phase 2 | [1] | ||
Company |
Novartis
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Structure |
![]() |
Download2D MOL |
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Formula |
C25H35N3O4
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Canonical SMILES |
CC(C)N(C(C)C)C(=O)C1=CC(=C(C=C1)OCCCCCOC2=CC=C(C=C2)C(=<br />N)N)O
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InChI |
1S/C25H35N3O4/c1-17(2)28(18(3)4)25(30)20-10-13-23(22(29)16-20)32-15-7-5-6-14-31-21-11-8-19(9-12-21)24(26)27/h8-13,16-18,29H,5-7,14-15H2,1-4H3,(H3,26,27)
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InChIKey |
LBVCAMSVLTWBRT-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Leukotriene B4 receptor 1 | Target Info | Antagonist | [2] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
NetPath Pathway | IL4 Signaling Pathway | ||||
Reactome | Leukotriene receptors | ||||
G alpha (q) signalling events | |||||
WikiPathways | Nucleotide GPCRs | ||||
GPCRs, Class A Rhodopsin-like | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
Spinal Cord Injury | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
References | |||||
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015581) | ||||
REF 2 | Effect of the oral leukotriene B4 receptor antagonist LTB019 on inflammatory sputum markers in patients with chronic obstructive pulmonary disease. Pulm Pharmacol Ther. 2008;21(2):409-17. | ||||
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