Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0N1GB
|
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| Former ID |
DIB010078
|
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| Drug Name |
APD-916
|
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| Synonyms |
Histamine H3 antagonists (sleep disorder), Arena; Biphenyl derivatives/aryl ethers/anilines (sleep disorder), Arena
|
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| Indication | Sleep disorders [ICD9: 307.4, 327, 780.5; ICD10:F51, G47] | Phase 1 | [1] | ||
| Company |
Arena Pharmaceuticals Inc
|
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| Structure |
|
Download2D MOL |
|||
| Canonical SMILES |
O=S(=O)(c1ccc(cc1)c1ccc(cc1)CCN1CCCC1C)NC1CCOCC1
|
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| Target and Pathway | |||||
| Target(s) | Histamine H3 receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Reactome | Histamine receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Monoamine Transport | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT01093508) Single-dose Safety Study of APD916 in Healthy Volunteers. U.S. National Institutes of Health. | ||||
| REF 2 | Identification of biaryl sulfone derivatives as antagonists of the histamine H??receptor: discovery of (R)-1-(2-(4'-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916). Bioorg Med Chem Lett. 2012 Jan 1;22(1):71-5. | ||||
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