| Drug General Information |
| Drug ID |
D0N2OM
|
| Former ID |
DNC000978
|
| Drug Name |
N,N-dialkyl-dipeptidylamines
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C27H25F2N3OS
|
| Canonical SMILES |
CC1=C(C(=O)N2C=CSC2=N1)CCN3CCC(=C(C4=CC=C(C=C4)F)C5=CC=<br />C(C=C5)F)CC3
|
| InChI |
1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
|
| InChIKey |
JUQLTPCYUFPYKE-UHFFFAOYSA-N
|
| CAS Number |
CAS 87051-43-2
|
| PubChem Compound ID |
|
| PubChem Substance ID |
855736, 7379883, 8149992, 8153123, 11111716, 11335367, 11360606, 11364744, 11367306, 11369868, 11372124, 11378033, 11461578, 11485176, 11489376, 11490838, 11495644, 12013534, 14834621, 17405639, 24278117, 26680887, 29224143, 47207399, 47216659, 47885282, 47959597, 48334360, 50057747, 50100336, 50104035, 50104036, 50104037, 50123110, 53301609, 53778189, 53788831, 56311639, 56423112, 57322596, 85089208, 85209702, 85231205, 85789270, 90340705, 91011597, 92303281, 92307929, 99301280, 103025197
|
| Target and Pathway |
| Target(s) |
Voltage-dependent N-type calcium channel |
Target Info |
Blocker |
[1]
|
|---|
|
KEGG Pathway
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MAPK signaling pathway
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Calcium signaling pathway
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Synaptic vesicle cycle
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Retrograde endocannabinoid signaling
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Cholinergic synapse
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Serotonergic synapse
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GABAergic synapse
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Dopaminergic synapse
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Taste transduction
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Type II diabetes mellitus
|
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Morphine addiction
|
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Nicotine addiction
|
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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Ionotropic glutamate receptor pathway
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Metabotropic glutamate receptor group III pathway
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Metabotropic glutamate receptor group II pathway
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Thyrotropin-releasing hormone receptor signaling pathway
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Endogenous cannabinoid signaling
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GABA-B receptor II signaling
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Reactome
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Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
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|
WikiPathways
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Calcium Regulation in the Cardiac Cell
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Synaptic Vesicle Pathway
|
| References |
| REF 1 | N,N-dialkyl-dipeptidylamines as novel N-type calcium channel blockers. Bioorg Med Chem Lett. 1999 Mar 22;9(6):907-12. |
|---|
