Drug Information

Drug General Information
Drug ID
D0N2QH
Former ID
DIB018653
Drug Name
5'-iodoresiniferatoxin
Synonyms
I-RTX
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467452]
Structure
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2D MOL

3D MOL
Formula
C37H39IO9
InChI
InChI=1S/C37H39IO9/c1-20(2)35-16-22(4)37-26(33(35)45-36(46-35,47-37)18-23-9-7-6-8-10-23)12-25(17-34(42)29(37)11-21(3)32(34)41)19-44-30(39)15-24-13-27(38)31(40)28(14-24)43-5/h6-14,22,26,29,33,40,42H,1,15-19H2,2-5H3/t22-,26+,29-,33-,34-,35-,36-,37-/m1/s1
InChIKey
TZUJORCXGLGWDV-DZBJMWFRSA-N
PubChem Compound ID
6324614
PubChem Substance ID
7979270, 49878785, 50753827, 85177269, 103716893, 104159639, 134347450, 135289475, 178100931
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Blocker (channel blocker) [543861]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 467452(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4109).
Ref 543861(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507).

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