Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0N3OH
|
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| Former ID |
DNC002332
|
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| Drug Name |
A-317920
|
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| Drug Type |
Small molecular drug
|
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| Indication | Attention deficit hyperactivity disorder [ICD9: 314; ICD10:F90] | Investigative | [1] | ||
| Company |
Abbott
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C25H31N3O5
|
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| InChI |
InChI=1S/C25H31N3O5/c1-18(26-24(30)22-4-2-16-33-22)25(31)28-14-12-27(13-15-28)11-3-17-32-21-9-7-20(8-10-21)23(29)19-5-6-19/h2,4,7-10,16,18-19H,3,5-6,11-15,17H2,1H3,(H,26,30)/t18-/m1/s1
|
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| InChIKey |
RTRADBQSZJIRMT-GOSISDBHSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Histamine H3 receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Reactome | Histamine receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Monoamine Transport | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1216). | ||||
| REF 2 | The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. | ||||
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