Drug Information

Drug General Information
Drug ID
D0N3ZJ
Former ID
DNC007741
Drug Name
LOMERIZINE
Drug Type
Small molecular drug
Indication Migraine [ICD9: 346; ICD10:G43] Approved [545070], [551871]
Structure
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2D MOL

3D MOL
Formula
C27H30F2N2O3
Canonical SMILES
COC1=C(C(=C(C=C1)CN2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=<br />C4)F)OC)OC
InChI
1S/C27H30F2N2O3/c1-32-24-13-8-21(26(33-2)27(24)34-3)18-30-14-16-31(17-15-30)25(19-4-9-22(28)10-5-19)20-6-11-23(29)12-7-20/h4-13,25H,14-18H2,1-3H3
InChIKey
JQSAYKKFZOSZGJ-UHFFFAOYSA-N
CAS Number
CAS 101477-55-8
PubChem Compound ID
3949
Target and Pathway
Target(s) Sodium channel protein type 5 subunit alpha Target Info Inhibitor [525961]
Voltage-dependent N-type calcium channel Target Info Inhibitor [528552]
Sodium channel Target Info Inhibitor [525961]
KEGG Pathway Adrenergic signaling in cardiomyocyteshsa04010:MAPK signaling pathway
Calcium signaling pathway
Synaptic vesicle cycle
Retrograde endocannabinoid signaling
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Taste transduction
Type II diabetes mellitus
Morphine addiction
Nicotine addictionhsa04728:Dopaminergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group II pathway
Thyrotropin-releasing hormone receptor signaling pathway
Endogenous cannabinoid signaling
GABA-B receptor II signaling
PathWhiz Pathway Muscle/Heart Contraction
Reactome Interaction between L1 and AnkyrinsR-HSA-112308:Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium ChannelsR-HSA-445095:Interaction between L1 and Ankyrins
WikiPathways SIDS Susceptibility Pathways
Cardiac Progenitor DifferentiationWP536:Calcium Regulation in the Cardiac Cell
Synaptic Vesicle Pathway
References
Ref 545070Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002033)
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 525961J Med Chem. 2001 Jan 18;44(2):115-37.Medicinal chemistry of neuronal voltage-gated sodium channel blockers.
Ref 528552Bioorg Med Chem Lett. 2007 Feb 1;17(3):662-7. Epub 2006 Nov 6.Synthesis and SAR of novel 2-arylthiazolidinones as selective analgesic N-type calcium channel blockers.

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