Drug General Information
Drug ID	D0N5CH
Former ID	DIB020035
Drug Name	ICA-27243
Synonyms	ICA 27243; ICA27243
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[1]
Structure		Download 2D MOL
Formula	C12H7ClF2N2O
InChI	InChI=1S/C12H7ClF2N2O/c13-11-4-2-8(6-16-11)17-12(18)7-1-3-9(14)10(15)5-7/h1-6H,(H,17,18)
InChIKey	GDGUOCFTHNGPBK-UHFFFAOYSA-N
PubChem Compound ID	9903497
PubChem Substance ID	14872594, 24185513, 45975168, 57373736, 74603414, 87350303, 87457385, 103562093, 117688381, 134225009, 138984654, 163369073, 172649959, 187072020, 198953729, 218903010, 223366002, 225374601, 226699778, 245792781
Target and Pathway
Target(s)	Potassium voltage-gated channel subfamily KQT member 2	Target Info	Activator	[2]
KEGG Pathway	Cholinergic synapse
PANTHER Pathway	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Reactome	Voltage gated Potassium channels
	Interaction between L1 and Ankyrins
WikiPathways	Potassium Channels
	L1CAM interactions
References
REF 1	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7667).
REF 2	The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site. Neurosci Lett. 2009 Nov 13;465(2):138-42.

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