Drug General Information
Drug ID	D0N5RQ
Former ID	DNC003620
Drug Name	KYS-05041
Indication	Discovery agent		Investigative	[528504]
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Voltage-dependent T-type calcium channel alpha-1G subunit	Target Info	Inhibitor	[528504]
	Voltage-dependent T-type calcium channel subunit alpha-1H	Target Info	Inhibitor	[527099]
KEGG Pathway	MAPK signaling pathway
	Calcium signaling pathway
	Circadian entrainment
	Type II diabetes mellitushsa04010:MAPK signaling pathway
PANTHER Pathway	Endogenous cannabinoid signaling
	GABA-B receptor II signaling
	Nicotine pharmacodynamics pathway
Pathway Interaction Database	Regulation of nuclear beta catenin signaling and target gene transcription
PathWhiz Pathway	Muscle/Heart ContractionPW000564:Muscle/Heart Contraction
Reactome	NCAM1 interactionsR-HSA-419037:NCAM1 interactions
WikiPathways	NCAM signaling for neurite out-growth
	Nicotine Activity on Chromaffin CellsWP2355:Corticotropin-releasing hormone
References
Ref 528504	Bioorg Med Chem. 2007 Jan 15;15(2):1091-105. Epub 2006 Oct 30.3D pharmacophore based virtual screening of T-type calcium channel blockers.
Ref 527099	Bioorg Med Chem Lett. 2004 Jul 5;14(13):3379-84.3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers.
Ref 528504	Bioorg Med Chem. 2007 Jan 15;15(2):1091-105. Epub 2006 Oct 30.3D pharmacophore based virtual screening of T-type calcium channel blockers.

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