Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0N5RQ
|
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| Former ID |
DNC003620
|
||||
| Drug Name |
KYS-05041
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Target and Pathway | |||||
| Target(s) | Voltage-dependent T-type calcium channel alpha-1G subunit | Target Info | Inhibitor | [1] | |
| Voltage-dependent T-type calcium channel subunit alpha-1H | Target Info | Inhibitor | [2] | ||
| KEGG Pathway | MAPK signaling pathway | ||||
| Calcium signaling pathway | |||||
| Circadian entrainment | |||||
| Type II diabetes mellitushsa04010:MAPK signaling pathway | |||||
| PANTHER Pathway | Endogenous cannabinoid signaling | ||||
| GABA-B receptor II signaling | |||||
| Nicotine pharmacodynamics pathway | |||||
| Pathway Interaction Database | Regulation of nuclear beta catenin signaling and target gene transcription | ||||
| PathWhiz Pathway | Muscle/Heart ContractionPW000564:Muscle/Heart Contraction | ||||
| Reactome | NCAM1 interactionsR-HSA-419037:NCAM1 interactions | ||||
| WikiPathways | NCAM signaling for neurite out-growth | ||||
| Nicotine Activity on Chromaffin CellsWP2355:Corticotropin-releasing hormone | |||||
| References | |||||
| REF 1 | Bioorg Med Chem. 2007 Jan 15;15(2):1091-105. Epub 2006 Oct 30.3D pharmacophore based virtual screening of T-type calcium channel blockers. | ||||
| REF 2 | Bioorg Med Chem Lett. 2004 Jul 5;14(13):3379-84.3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers. | ||||
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