Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0N6IG
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| Former ID |
DIB002307
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| Drug Name |
H3 receptor inverse agonists
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| Synonyms |
H3 receptor inverse agonists (CNS disorders, obesity); H3 receptor inverse agonists(CNS disorders, obesity), Roche
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| Indication | Central nervous system disease [ICD10:G00-G99] | Investigative | [1] | ||
| Company |
F Hoffmann-La Roche Ltd
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| Structure |
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Download2D MOL |
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| Canonical SMILES |
C(=O)(c1n(c2c(c1)cc(cc2)OC1CCN(CC1)C(C)C)C(C)C)N1CCC(CC<br />1)(F)F
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| Target and Pathway | |||||
| Target(s) | Histamine H3 receptor | Target Info | Agonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Reactome | Histamine receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Monoamine Transport | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Discovery of potent and selective histamine H3 receptor inverse agonists based on the 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one scaffold. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5713-7 | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 264). | ||||
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