Drug General Information
Drug ID
D0N6OL
Former ID
DNC006945
Drug Name
ADS-103253
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528581]
Structure
Download
2D MOL

3D MOL

Formula
C21H21ClN4O2
Canonical SMILES
CC1=NC(=NC2=C1C=C(C=C2)NC(=O)COC3=CC=C(C=C3)Cl)N4CCCC4
InChI
1S/C21H21ClN4O2/c1-14-18-12-16(24-20(27)13-28-17-7-4-15(22)5-8-17)6-9-19(18)25-21(23-14)26-10-2-3-11-26/h4-9,12H,2-3,10-11,13H2,1H3,(H,24,27)
InChIKey
MXDQNCXNQJMIEH-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Melanin-concentrating hormone receptor 1 Target Info Inhibitor [528581]
Potassium voltage-gated channel subfamily H member 2 Target Info Inhibitor [528581]
5-hydroxytryptamine 2B receptor Target Info Inhibitor [528581]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling eventsR-HSA-1296072:Voltage gated Potassium channelsR-HSA-390666:Serotonin receptors
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
Hematopoietic Stem Cell Differentiation
Potassium ChannelsWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCR downstream signaling
References
Ref 528581Bioorg Med Chem Lett. 2007 Mar 1;17(5):1403-7. Epub 2006 Dec 2.Quinazoline and benzimidazole MCH-1R antagonists.
Ref 528581Bioorg Med Chem Lett. 2007 Mar 1;17(5):1403-7. Epub 2006 Dec 2.Quinazoline and benzimidazole MCH-1R antagonists.

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