Drug General Information
Drug ID	D0N7MQ
Former ID	DIB013968
Drug Name	Small molecule 33
Synonyms	IDDBCP233389
Indication	Congestive heart failure [ICD9: 428; ICD10:I50]		Investigative	[543921]
Company	Evotec AG
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(ccc(cc1)c1ccc(cc1)C(=O)N1CCC(CC1)Cc1[nH]ccn1)F
Target and Pathway
Target(s)	5-hydroxytryptamine 2B receptor	Target Info	Antagonist	[543921]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	5HT2 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (q) signalling events
WikiPathways	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 543921	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 7).
Ref 543921	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 7).

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