Drug Information

Drug General Information
Drug ID
D0N8AO
Former ID
DNC006783
Drug Name
4-(4-benzenesulfonamidophenyl)piperazine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528373]
Structure
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2D MOL

3D MOL
Formula
C16H19N3O2S
Canonical SMILES
C1CN(CCN1)C2=CC=C(C=C2)NS(=O)(=O)C3=CC=CC=C3
InChI
1S/C16H19N3O2S/c20-22(21,16-4-2-1-3-5-16)18-14-6-8-15(9-7-14)19-12-10-17-11-13-19/h1-9,17-18H,10-13H2
InChIKey
LHOHHFFMBNKDDU-UHFFFAOYSA-N
PubChem Compound ID
11849789
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [528373]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 528373J Med Chem. 2006 Aug 24;49(17):5217-25.Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors.
Ref 528373J Med Chem. 2006 Aug 24;49(17):5217-25.Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors.

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