Drug Information

Drug General Information
Drug ID
D0N9ZP
Former ID
DNC000105
Drug Name
8-amino-5'-deoxy-5'-chloroguanosine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [537731]
Structure
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2D MOL

3D MOL
Formula
C24H34N2O4+2
Canonical SMILES
C[N+]1(CCOC(C1)(C2=CC=C(C=C2)C3=CC=C(C=C3)C4(C[N+](CCO4<br />)(C)C)O)O)C
InChI
1S/C24H34N2O4/c1-25(2)13-15-29-23(27,17-25)21-9-5-19(6-10-21)20-7-11-22(12-8-20)24(28)18-26(3,4)14-16-30-24/h5-12,27-28H,13-18H2,1-4H3/q+2
InChIKey
JIWUESGGKYLPPG-UHFFFAOYSA-N
PubChem Compound ID
3585
PubChem Substance ID
7440465, 8152261, 11466421, 11467541, 11486262, 26756595, 29222711, 47365421, 47365422, 47885612, 48185192, 48259465, 49698469, 49994532, 50070722, 50111083, 50381698, 57321877, 85209525, 90341031, 103107979, 103170774, 104303932, 114916412, 117613891, 124749826, 124880252, 128281574, 129212665, 134339628, 134339629, 134340080, 135073722, 136351306, 137008799, 141867156, 142312972, 160849790, 162800225, 178101222, 179236191, 237684190
Target and Pathway
Target(s) Purine nucleoside phosphorylase Target Info Inhibitor [537731]
BioCyc Pathway Arsenate detoxification I (glutaredoxin)
Purine nucleotides degradation
Urate biosynthesis/inosine 5'-phosphate degradation
Purine deoxyribonucleosides degradation
Purine ribonucleosides degradation to ribose-1-phosphate
Guanosine nucleotides degradation
Adenosine nucleotides degradation
Superpathway of purine nucleotide salvage
Adenine and adenosine salvage III
Guanine and guanosine salvage
KEGG Pathway Purine metabolism
Pyrimidine metabolism
Nicotinate and nicotinamide metabolism
Metabolic pathways
NetPath Pathway TCR Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Adenine and hypoxanthine salvage pathway
Xanthine and guanine salvage pathway
PathWhiz Pathway Purine Metabolism
Nicotinate and Nicotinamide Metabolism
Reactome Purine salvage
Purine catabolism
WikiPathways miR-targeted genes in squamous cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
Metabolism of nucleotides
References
Ref 537731Expression of human malaria parasite purine nucleoside phosphorylase in host enzyme-deficient erythrocyte culture. Enzyme characterization and identification of novel inhibitors. J Biol Chem. 1986 Sep 5;261(25):11667-73.
Ref 537731Expression of human malaria parasite purine nucleoside phosphorylase in host enzyme-deficient erythrocyte culture. Enzyme characterization and identification of novel inhibitors. J Biol Chem. 1986 Sep 5;261(25):11667-73.

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