Drug General Information
Drug ID
D0ND2Y
Former ID
DNC011941
Drug Name
1-(3-Nitro-phenyl)-piperazine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533134]
Structure
Download
2D MOL

3D MOL

Formula
C10H13N3O2
Canonical SMILES
C1CN(CCN1)C2=CC(=CC=C2)[N+](=O)[O-]
InChI
1S/C10H13N3O2/c14-13(15)10-3-1-2-9(8-10)12-6-4-11-5-7-12/h1-3,8,11H,4-7H2
InChIKey
LHHZRIYUOZPKSG-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) 5-hydroxytryptamine 1D receptor Target Info Inhibitor [533134]
5-hydroxytryptamine 1A receptor Target Info Inhibitor [533134]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
GPCR downstream signaling
References
Ref 533134J Med Chem. 1989 May;32(5):1052-6.Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.
Ref 533134J Med Chem. 1989 May;32(5):1052-6.Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.

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