Drug Information

Drug General Information
Drug ID
D0NJ4H
Former ID
DNC006614
Drug Name
MORIN
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467453]
Structure
Download
2D MOL

3D MOL
Formula
C15H10O7
InChI
InChI=1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H
InChIKey
YXOLAZRVSSWPPT-UHFFFAOYSA-N
PubChem Compound ID
5281670
PubChem Substance ID
12291, 82595, 597188, 855692, 3133996, 4350240, 8138036, 8149869, 8616709, 11111456, 11336133, 11361372, 11364128, 11366690, 11369252, 11372921, 11375406, 11377414, 11406040, 11462344, 11484665, 11488531, 11491756, 11493738, 11495048, 11537743, 12161501, 14776187, 17405337, 24885989, 26612364, 26680105, 26746965, 26746966, 29204411, 39290452, 47365282, 47515389, 47515390, 47736574, 47736575, 48110526, 48259328, 48421904, 49748184, 49970076, 50100276, 50104016, 50104017, 50104018
Target and Pathway
Target(s) Estrogen receptor beta Target Info Inhibitor [531262]
Beta-hydroxyacyl-acp dehydratase Target Info Inhibitor [528213]
Solute carrier family 22 member 12 Target Info Inhibitor [528700]
Fatty acid synthase Target Info Inhibitor [528213]
3-oxoacyl-[acyl-carrier protein] reductase Target Info Inhibitor [528213]
Induced myeloid leukemia cell differentiation protein Mcl-1 Target Info Inhibitor [531262]
Enoyl-ACP reductase Target Info Inhibitor [528213]
BioCyc Pathway Fatty acid biosynthesis initiation
Fatty acid elongation -- saturated
Palmitate biosynthesis
KEGG Pathway Estrogen signaling pathway
Prolactin signaling pathwaypfa00061:Fatty acid biosynthesis
Biotin metabolism
Metabolic pathways
Fatty acid metabolismhsa00061:Fatty acid biosynthesis
Metabolic pathways
Fatty acid metabolism
AMPK signaling pathway
Insulin signaling pathwayhsa04151:PI3K-Akt signaling pathway
MicroRNAs in cancer
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
CCKR signaling map ST
Pathway Interaction Database Plasma membrane estrogen receptor signaling
Validated nuclear estrogen receptor beta network
Validated nuclear estrogen receptor alpha networkp73pathway:p73 transcription factor network
Validated transcriptional targets of deltaNp63 isoformse2f_pathway:E2F transcription factor network
Direct p53 effectors
IL6-mediated signaling events
HIF-1-alpha transcription factor network
PathWhiz Pathway Fatty Acid Biosynthesis
Reactome Nuclear Receptor transcription pathwayR-HSA-163765:ChREBP activates metabolic gene expression
Activation of gene expression by SREBF (SREBP)
Fatty Acyl-CoA Biosynthesis
WikiPathways SIDS Susceptibility Pathways
Ovarian Infertility Genes
Integrated Pancreatic Cancer Pathway
Nuclear ReceptorsWP1935:Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP357:Fatty Acid Biosynthesis
Nuclear Receptors Meta-Pathway
Liver X Receptor Pathway
Activation of Gene Expression by SREBP (SREBF)
SREBF and miR33 in cholesterol and lipid homeostasis
SREBP signalling
Metabolism of water-soluble vitamins and cofactors
Integration of energy metabolism
Fatty acid, triacylglycerol, and ketone body metabolism
AMPK SignalingWP254:Apoptosis
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
Apoptosis Modulation and Signaling
References
Ref 467453(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 411).
Ref 528213J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.
Ref 528700Drug Metab Dispos. 2007 Jun;35(6):981-6. Epub 2007 Feb 26.Morin (3,5,7,2',4'-pentahydroxyflavone) exhibits potent inhibitory actions on urate transport by the human urate anion transporter (hURAT1) expressed in human embryonic kidney cells.
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).

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