Drug General Information
Drug ID	D0NU1W
Former ID	DNC005190
Drug Name	3,6,8-Tribromo-dibenzo[1,4]dioxin-1-ol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527145]
Structure		Download 2D MOL 3D MOL
Formula	C12H5Br3O3
Canonical SMILES	C1=C(C=C2C(=C1O)OC3=CC(=CC(=C3O2)Br)Br)Br
InChI	1S/C12H5Br3O3/c13-5-1-7(15)11-9(3-5)18-12-8(16)2-6(14)4-10(12)17-11/h1-4,16H
InChIKey	XZPITRJUKODSMI-UHFFFAOYSA-N
PubChem Compound ID	636835
Target and Pathway
Target(s)	Arachidonate 15-lipoxygenase	Target Info	Inhibitor	[527145]
BioCyc Pathway	Resolvin D biosynthesis
	Lipoxin biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Linoleic acid metabolism
	Metabolic pathways
	Serotonergic synapse
NetPath Pathway	IL4 Signaling Pathway
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database	IL4-mediated signaling events
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Arachidonic acid metabolism
	Eicosanoid Synthesis
References
Ref 527145	J Med Chem. 2004 Jul 29;47(16):4060-5.Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase.
Ref 527145	J Med Chem. 2004 Jul 29;47(16):4060-5.Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase.

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