Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0NW2B
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| Former ID |
DIB010242
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| Drug Name |
NK3 antagonist PET ligand
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| Synonyms |
NK3 antagonist PET ligand (psychiatric disease); NK3 antagonist PET ligand (psychiatric disease), AstraZeneca
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| Indication | Psychiatric disorder [ICD9: 290-319; ICD10:F01-F99] | Investigative | [1] | ||
| Company |
AstraZeneca plc
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
c1ccc2c(c1)c(c(c(n2)c1ccccc1)[S@@](=O)C)C(=O)N[C@H](c1c<br />cccc1)CC
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| Target and Pathway | |||||
| Target(s) | Nigral tachykinin NK(3) receptor | Target Info | Antagonist | [1] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Reactome | G alpha (q) signalling events | ||||
| WikiPathways | Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 362). | ||||
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