Drug Information

Drug General Information
Drug ID
D0NW3X
Former ID
DAP000495
Drug Name
Dofetilide
Synonyms
Dofetilida; Dofetilidum; Tikosyn; Xelide; UK 68798; Dofetilida [INN-Spanish]; Dofetilidum [INN-Latin];Tikosyn (TN); UK 68,798; UK-68798; Dofetilide [USAN:BAN:INN]; Tikosyn, UK68798, Dofetilide; UK-68,798; Dofetilide (JAN/USAN/INN); Beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide; N-[4-[2-[2-[4-(methanesulfonamido)phenoxy]ethyl-methylamino]ethyl]phenyl]methanesulfonamide; N-(4-{2-[methyl(2-{4-[(methylsulfonyl)amino]phenoxy}ethyl)amino]ethyl}phenyl)methanesulfonamide; Methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl)phenyl); 1-(4-methanesulfonamidophenoxy)-2-(N-(4-methanesulfonamidophenethyl)-N-methylamine)ethane; 1-MSPMPE
Drug Type
Small molecular drug
Indication Maintenance of normal sinus rhythm [ICD9: 427; ICD10:I46-I49] Approved [536095], [539681]
Therapeutic Class
Antiarrhythmic Agents
Company
Pfizer Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C19H27N3O5S2
InChI
InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3
InChIKey
IXTMWRCNAAVVAI-UHFFFAOYSA-N
CAS Number
CAS 115256-11-6
PubChem Compound ID
71329
PubChem Substance ID
9953, 6866968, 7847713, 7979117, 8194566, 11528674, 12014163, 14832836, 26719840, 26757968, 43127674, 46386638, 46509127, 49681772, 49830467, 50139453, 50845418, 57318136, 81041120, 87350381, 92308504, 92308779, 92719410, 103168841, 103940282, 104253292, 104350198, 117632008, 119526323, 121361247, 124659024, 124757413, 124800159, 125001905, 125164217, 125338634, 126620831, 126658284, 126670949, 128235810, 131295440, 131542548, 134337788, 135028787, 135650201, 135692215, 136946393, 137005478, 140086817, 144115915
ChEBI ID
ChEBI:4681
SuperDrug ATC ID
C01BD04
SuperDrug CAS ID
cas=115256116
Target and Pathway
Target(s) Potassium channel Target Info Modulator [556264]
References
Ref 536095New antiarrhythmic agents for atrial fibrillation and atrial flutter. Expert Opin Emerg Drugs. 2005 May;10(2):311-22.
Ref 539681(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2604).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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