Drug Information

Drug General Information
Drug ID
D0O0JO
Former ID
DNC011256
Drug Name
N-(2-chlorobenzyl)-5-(4-chlorophenyl)nicotinamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531169]
Structure
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2D MOL

3D MOL
Formula
C19H14Cl2N2O
Canonical SMILES
C1=CC=C(C(=C1)CNC(=O)C2=CN=CC(=C2)C3=CC=C(C=C3)Cl)Cl
InChI
1S/C19H14Cl2N2O/c20-17-7-5-13(6-8-17)15-9-16(11-22-10-15)19(24)23-12-14-3-1-2-4-18(14)21/h1-11H,12H2,(H,23,24)
InChIKey
CKNIOMWTEPBNFF-UHFFFAOYSA-N
PubChem Compound ID
52948346
Target and Pathway
Target(s) PN3 Na+ channel Target Info Inhibitor [531169]
Voltage-gated sodium channel subunit alpha Nav1.8 Target Info Inhibitor [531169]
Reactome Interaction between L1 and Ankyrins
References
Ref 531169Bioorg Med Chem Lett. 2010 Nov 15;20(22):6812-5. Epub 2010 Sep 18.Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives.
Ref 531169Bioorg Med Chem Lett. 2010 Nov 15;20(22):6812-5. Epub 2010 Sep 18.Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives.

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