Drug Information
Drug General Information | |||||
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Drug ID |
D0O7DA
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Former ID |
DNC003916
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Drug Name |
(+)-BUTACLAMOL
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [541370] | ||
Structure |
Download2D MOL |
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Formula |
C25H31NO
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InChI |
InChI=1S/C25H31NO/c1-24(2,3)25(27)13-14-26-16-21-19-9-5-4-7-17(19)11-12-18-8-6-10-20(23(18)21)22(26)15-25/h4-10,21-22,27H,11-16H2,1-3H3/t21-,22-,25-/m0/s1
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InChIKey |
ZZJYIKPMDIWRSN-HWBMXIPRSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | D(3) dopamine receptor | Target Info | Inhibitor | [529789] | |
D(2) dopamine receptor | Target Info | Inhibitor | [527368] | ||
Dopamine D1 receptor | Target Info | Inhibitor | [525773] | ||
Adenosine A3 receptor | Target Info | Inhibitor | [527823] | ||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
Dopamine receptor mediated signaling pathway | |||||
Nicotine pharmacodynamics pathwayP05912:Dopamine receptor mediated signaling pathway | |||||
PathWhiz Pathway | Dopamine Activation of Neurological Reward System | ||||
WikiPathways | Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
Nicotine Activity on Dopaminergic Neurons | |||||
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction | |||||
Genes and (Common) Pathways Underlying Drug Addiction | |||||
Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction | |||||
GPCR downstream signalingWP80:Nucleotide GPCRs | |||||
GPCRs, Other | |||||
References | |||||
Ref 525773 | J Med Chem. 2000 May 18;43(10):2079-81.7-Methyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecine: a new heterocyclic system and a new lead compound for dopamine receptor antagonists. | ||||
Ref 527368 | J Med Chem. 2005 Jan 13;48(1):266-73.Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands. | ||||
Ref 527823 | J Med Chem. 2005 Nov 3;48(22):6887-96.2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. | ||||
Ref 529789 | J Med Chem. 2008 Nov 27;51(22):7094-8.cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia. |
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