Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0O7KO
|
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| Former ID |
DIB018845
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| Drug Name |
AMPA
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C7H10N2O4
|
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| InChI |
InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
|
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| InChIKey |
UUDAMDVQRQNNHZ-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
586264, 3153188, 4604327, 4621378, 7978698, 8151038, 14992877, 24439566, 24891141, 47365478, 47959968, 48334712, 50065198, 50104319, 53790328, 53800976, 57320821, 80658539, 84933918, 85083665, 85208893, 88802094, 90340931, 103174429, 103916675, 104297107, 117405204, 117682320, 118507695, 124749829, 124880176, 125378210, 126602144, 129420984, 131332141, 134348611, 135011151, 135112645, 135676919, 136345218, 137010348, 137132925, 137323835, 142164125, 143551527, 162022443, 162040454, 162110094, 162220190, 163127058
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| Target and Pathway | |||||
| Target(s) | Glutamate receptor 2 | Target Info | Agonist | [2] | |
| Glutamate receptor 1 | Target Info | Agonist | [3] | ||
| Glutamate receptor 3 | Target Info | Agonist | [4] | ||
| Glutamate receptor 4 | Target Info | Agonist | [5] | ||
| KEGG Pathway | cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Circadian entrainment | |||||
| Long-term potentiation | |||||
| Retrograde endocannabinoid signaling | |||||
| Glutamatergic synapse | |||||
| Dopaminergic synapse | |||||
| Long-term depression | |||||
| Amyotrophic lateral sclerosis (ALS) | |||||
| Amphetamine addiction | |||||
| Nicotine addictionhsa04024:cAMP signaling pathway | |||||
| Nicotine addiction | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Ionotropic glutamate receptor pathway | ||||
| Metabotropic glutamate receptor group III pathwayP00037:Ionotropic glutamate receptor pathway | |||||
| Metabotropic glutamate receptor group III pathway | |||||
| Pathway Interaction Database | N-cadherin signaling eventsephbfwdpathway:EPHB forward signaling | ||||
| Reactome | COPII (Coat Protein 2) Mediated Vesicle Transport | ||||
| Trafficking of AMPA receptors | |||||
| Trafficking of GluR2-containing AMPA receptors | |||||
| Unblocking of NMDA receptor, glutamate binding and activation | |||||
| Cargo concentration in the ERR-HSA-399719:Trafficking of AMPA receptors | |||||
| WikiPathways | Hypothetical Network for Drug Addiction | ||||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
| Amyotrophic lateral sclerosis (ALS) | |||||
| BDNF signaling pathwayWP666:Hypothetical Network for Drug Addiction | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4131). | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 445). | ||||
| REF 3 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 444). | ||||
| REF 4 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 446). | ||||
| REF 5 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 447). | ||||
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