Drug Information

Drug General Information
Drug ID
D0O7KO
Former ID
DIB018845
Drug Name
AMPA
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467476]
Structure
Download
2D MOL
Formula
C7H10N2O4
InChI
InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
InChIKey
UUDAMDVQRQNNHZ-UHFFFAOYSA-N
PubChem Compound ID
1221
PubChem Substance ID
586264, 3153188, 4604327, 4621378, 7978698, 8151038, 14992877, 24439566, 24891141, 47365478, 47959968, 48334712, 50065198, 50104319, 53790328, 53800976, 57320821, 80658539, 84933918, 85083665, 85208893, 88802094, 90340931, 103174429, 103916675, 104297107, 117405204, 117682320, 118507695, 124749829, 124880176, 125378210, 126602144, 129420984, 131332141, 134348611, 135011151, 135112645, 135676919, 136345218, 137010348, 137132925, 137323835, 142164125, 143551527, 162022443, 162040454, 162110094, 162220190, 163127058
Target and Pathway
Target(s) Glutamate receptor 2 Target Info Agonist [543828]
Glutamate receptor 1 Target Info Agonist [543827]
Glutamate receptor 3 Target Info Agonist [543829]
Glutamate receptor 4 Target Info Agonist [543830]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Dopaminergic synapse
Long-term depression
Amyotrophic lateral sclerosis (ALS)
Amphetamine addiction
Nicotine addictionhsa04024:cAMP signaling pathway
Nicotine addiction
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathwayP00037:Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Pathway Interaction Database N-cadherin signaling eventsephbfwdpathway:EPHB forward signaling
Reactome COPII (Coat Protein 2) Mediated Vesicle Transport
Trafficking of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation
Cargo concentration in the ERR-HSA-399719:Trafficking of AMPA receptors
WikiPathways Hypothetical Network for Drug Addiction
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Amyotrophic lateral sclerosis (ALS)
BDNF signaling pathwayWP666:Hypothetical Network for Drug Addiction
References
Ref 467476(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4131).
Ref 543827(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 444).
Ref 543828(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 445).
Ref 543829(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 446).
Ref 543830(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 447).

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