Drug General Information
Drug ID	D0O7MW
Former ID	DNC011274
Drug Name	(5-methoxy-1H-indol-3-yl)methanamine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[531223]
Structure		Download 2D MOL 3D MOL
Formula	C10H12N2O
Canonical SMILES	COC1=CC2=C(C=C1)NC=C2CN
InChI	1S/C10H12N2O/c1-13-8-2-3-10-9(4-8)7(5-11)6-12-10/h2-4,6,12H,5,11H2,1H3
InChIKey	CAHOMULUOHSWPI-UHFFFAOYSA-N
PubChem Compound ID	14702424
Target and Pathway
Target(s)	5-hydroxytryptamine 2B receptor	Target Info	Inhibitor	[531223]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	5HT2 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (q) signalling events
WikiPathways	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 531223	J Med Chem. 2010 Nov 11;53(21):7573-86.Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs.
Ref 531223	J Med Chem. 2010 Nov 11;53(21):7573-86.Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs.

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