Drug General Information
Drug ID
D0O8JQ
Former ID
DNC009317
Drug Name
KNI-10256
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529771]
Structure
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2D MOL

3D MOL

Formula
C33H36N4O8S
Canonical SMILES
CC1(C(N(CS1)C(=O)C(C(CC2=CC=CC=C2)NC(=O)COC3=CC=C(C=C3)<br />[N+](=O)[O-])O)C(=O)NC4C(CC5=CC=CC=C45)O)C
InChI
1S/C33H36N4O8S/c1-33(2)30(31(41)35-28-24-11-7-6-10-21(24)17-26(28)38)36(19-46-33)32(42)29(40)25(16-20-8-4-3-5-9-20)34-27(39)18-45-23-14-12-22(13-15-23)37(43)44/h3-15,25-26,28-30,38,40H,16-19H2,1-2H3,(H,34,39)(H,35,41)/t25-,26+,28-,29-,30+/m0/s1
InChIKey
PABVKNPJQYYVNK-DOWNBTJOSA-N
PubChem Compound ID
Target and Pathway
Target(s) Plasmepsin 2 Target Info Inhibitor [529771]
References
Ref 529771Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. Epub 2008 Oct 10.Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin.
Ref 529771Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. Epub 2008 Oct 10.Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin.

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