Drug Information

Drug General Information
Drug ID
D0O9XO
Former ID
DIB003312
Drug Name
KH-902
Synonyms
Fumintide; KH-902 (intravitreal, AMD/DME), Kanghong Biotechnologies
Indication Diabetic macular edema [ICD9: 250, 362.01, 362.07, 362.53, 782.3; ICD10:E08-E13, E08.3, E09.3, E10.3, E11.3, E13.3, H35.8, R60.9] Phase 3 [523629]
Company
Chengdu Kanghong Biotechnologies Co Ltd
Target and Pathway
Target(s) VEGF receptor Target Info Modulator [531802]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Focal adhesion
Transcriptional misregulation in cancer
Rheumatoid arthritis
References
Ref 523629ClinicalTrials.gov (NCT01436864) A Randomized, Double-masked, Multicenter,Sham-controlled, Safety and Efficacy Study of KH902 in Patients With Wet AMD. U.S. National Institutes of Health.
Ref 531802Effects of intravitreal injection of KH902, a vascular endothelial growth factor receptor decoy, on the retinas of streptozotocin-induced diabetic rats. Diabetes Obes Metab. 2012 Jul;14(7):644-53.

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