Drug Information

Drug General Information
Drug ID
D0OH1O
Former ID
DIB016031
Drug Name
VULM-1457
Synonyms
Acyl CoA cholesterol acyltransferase inhibitor (dyslipidemia/atherosclerosis), Univerzity Komenskeho v Bratislave
Indication Atherosclerosis [ICD9: 414.0, 440; ICD10:I70] Investigative [543651]
Company
Univerzity Komenskeho v Bratislave
Structure
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2D MOL

3D MOL
Canonical SMILES
c1(NC(=O)Nc2ccc(Sc3ccc([N+](=O)[O-])cc3)cc2)c(C(C)C)ccc<br />c1C(C)C
Target and Pathway
Target(s) Liver carboxylesterase Target Info Inhibitor [543651]
KEGG Pathway Drug metabolism - other enzymes
Metabolic pathways
Pathway Interaction Database E2F transcription factor network
WikiPathways NRF2 pathway
Nuclear Receptors Meta-Pathway
Heroin metabolism
Irinotecan Pathway
Fluoropyrimidine Activity
Phase I biotransformations, non P450
References
Ref 543651(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2592).
Ref 543651(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2592).

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