Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0OW2O
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| Former ID |
DNC004379
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| Drug Name |
U-92032
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Terminated | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C30H35F2N3O2
|
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| Canonical SMILES |
CC(C)C1=CC=C(C(=O)C(=C1)NCCO)CN2CCN(CC2)C(C3=CC=C(C=C3)<br />F)C4=CC=C(C=C4)F
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| InChI |
1S/C30H35F2N3O2/c1-21(2)24-3-4-25(30(37)28(19-24)33-13-18-36)20-34-14-16-35(17-15-34)29(22-5-9-26(31)10-6-22)23-7-11-27(32)12-8-23/h3-12,19,21,29,36H,13-18,20H2,1-2H3,(H,33,37)
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| InChIKey |
UVPCKMJVJLKETQ-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Voltage-dependent T-type calcium channel alpha-1I subunit | Target Info | Inhibitor | [2] | |
| Sodium channel | Target Info | Inhibitor | [2] | ||
| Voltage-dependent T-type calcium channel subunit alpha-1H | Target Info | Inhibitor | [2] | ||
| Voltage-gated sodium channel subunit alpha Nav1.3 | Target Info | Inhibitor | [2] | ||
| KEGG Pathway | MAPK signaling pathway | ||||
| Calcium signaling pathway | |||||
| Circadian entrainmenthsa04728:Dopaminergic synapsehsa04010:MAPK signaling pathway | |||||
| Calcium signaling pathway | |||||
| Circadian entrainment | |||||
| PathWhiz Pathway | Muscle/Heart Contraction | ||||
| Reactome | Interaction between L1 and AnkyrinsR-HSA-419037:NCAM1 interactionsR-HSA-445095:Interaction between L1 and Ankyrins | ||||
| WikiPathways | Corticotropin-releasing hormone | ||||
| NCAM signaling for neurite out-growth | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004258) | ||||
| REF 2 | J Med Chem. 2000 Sep 7;43(18):3372-6.Discovery of (2S)-1-(4-amino-2,3,5- trimethylphenoxy)-3-[4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl]-2-propanol dimethanesulfonate (SUN N8075): a dual Na(+) and Ca(2+) channel blocker with antioxidant activity. | ||||
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