Drug Information

Drug General Information
Drug ID
D0P0GT
Former ID
DNC002630
Drug Name
Cycloleucine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551384]
Structure
Download
2D MOL

3D MOL
Formula
C6H11NO2
Canonical SMILES
C1CCC(C1)(C(=O)O)N
InChI
1S/C6H11NO2/c7-6(5(8)9)3-1-2-4-6/h1-4,7H2,(H,8,9)
InChIKey
NILQLFBWTXNUOE-UHFFFAOYSA-N
CAS Number
CAS 52-52-8
PubChem Compound ID
2901
PubChem Substance ID
6689, 67889, 610376, 3131911, 6436540, 7407703, 7885664, 8136892, 8149835, 8151856, 10525255, 11335898, 11361137, 11364162, 11366724, 11369286, 11372786, 11373858, 11377448, 11404465, 11447323, 11462109, 11484598, 11488747, 11491329, 11492155, 11495082, 15194490, 24846087, 24890914, 26612314, 26679236, 26748625, 26748626, 26756618, 29222054, 46393608, 46505671, 47515338, 47885435, 48185016, 48259251, 48334508, 48422156, 48435965, 49854394, 50122828, 51073752, 57321507, 57777606
Target and Pathway
Target(s) NMDA receptor subunit NR1 Target Info Inhibitor [551384]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Long-term potentiation
Glutamatergic synapse
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Cocaine addiction
Amphetamine addiction
Nicotine addiction
Alcoholism
PANTHER Pathway Huntington disease
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Reactome EPHB-mediated forward signaling
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
RAF/MAP kinase cascade
WikiPathways SIDS Susceptibility Pathways
Hypothetical Network for Drug Addiction
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Spinal Cord Injury
BDNF signaling pathway
Alzheimers Disease
References
Ref 551384Effects of D-cycloserine and cycloleucine, ligands for the <span class="caps">NMDA</span>-associated strychnine-insensitive glycine site, on brain-stimulation reward and spontaneous locomotion. Pharmacol Biochem Behav. 1990 Aug;36(4):735-8.
Ref 551384Effects of D-cycloserine and cycloleucine, ligands for the <span class="caps">NMDA</span>-associated strychnine-insensitive glycine site, on brain-stimulation reward and spontaneous locomotion. Pharmacol Biochem Behav. 1990 Aug;36(4):735-8.

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