Drug General Information
Drug ID
D0P0SM
Former ID
DAP001345
Drug Name
Almogran
Synonyms
Almotriptan; Axert; Almotriptan (USAN); Axert (TN); LAS-31416; PNU-180638; Almotriptan [USAN:INN:BAN]; N,N-dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]ethanamine; N,N-dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamine; 1-(((3-(2-(Dimethylamino)ethyl)indol-5-yl)methyl)sulfonyl)pyrrolidine
Drug Type
Small molecular drug
Indication Migraine [ICD9: 346; ICD10:G43] Approved [550661]
Therapeutic Class
Antimigraine Agents
Company
Almirall Prodesfarma
Structure
Download
2D MOL

3D MOL

Formula
C17H25N3O2S
Canonical SMILES
CN(C)CCC1=CNC2=C1C=C(C=C2)CS(=O)(=O)N3CCCC3
InChI
1S/C17H25N3O2S/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3
InChIKey
WKEMJKQOLOHJLZ-UHFFFAOYSA-N
CAS Number
CAS 154323-57-6
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
N02CC05
SuperDrug CAS ID
cas=154323576
Target and Pathway
Target(s) 5-hydroxytryptamine 1D receptor Target Info Agonist [535330]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 550661Drug information of Almogran, 2008. eduDrugs.
Ref 535330Efficacy and tolerability of subcutaneous almotriptan for the treatment of acute migraine: a randomized, double-blind, parallel-group, dose-finding study. Clin Ther. 2001 Nov;23(11):1867-75.

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