Drug Information

Drug General Information
Drug ID
D0P1BK
Former ID
DNC001001
Drug Name
NC1153
Drug Type
Small molecular drug
Indication Renal transplantation [ICD9: 279.5; ICD10:D89.8] Investigative [536279]
Structure
Download
2D MOL

3D MOL
Formula
C18H38Cl2N2O
Canonical SMILES
CN(C)CC1CCCCCCCCCC(C1=O)CN(C)C.Cl.Cl
InChI
1S/C18H36N2O.2ClH/c1-19(2)14-16-12-10-8-6-5-7-9-11-13-17(18(16)21)15-20(3)4;;/h16-17H,5-15H2,1-4H3;2*1H
InChIKey
GHMOOTNSJIQWGK-UHFFFAOYSA-N
PubChem Compound ID
11696352
PubChem Substance ID
16800856, 42863265, 77342674, 134340270
Target and Pathway
Target(s) Tyrosine-protein kinase JAK3 Target Info Inhibitor [536279]
KEGG Pathway Chemokine signaling pathway
PI3K-Akt signaling pathway
Signaling pathways regulating pluripotency of stem cells
Jak-STAT signaling pathway
Measles
HTLV-I infection
Epstein-Barr virus infection
Viral carcinogenesis
Primary immunodeficiency
PANTHER Pathway Interleukin signaling pathway
JAK/STAT signaling pathway
PDGF signaling pathway
Pathway Interaction Database IL4-mediated signaling events
CD40/CD40L signaling
Signaling events mediated by TCPTP
SHP2 signaling
IL2-mediated signaling events
IL2 signaling events mediated by PI3K
IL2 signaling events mediated by STAT5
Reactome GPVI-mediated activation cascade
Interleukin-7 signaling
G beta:gamma signalling through PI3Kgamma
Interleukin-2 signaling
RAF/MAP kinase cascade
Interleukin receptor SHC signaling
WikiPathways IL-2 Signaling Pathway
IL-4 Signaling Pathway
Interleukin-2 signaling
Interleukin-7 signaling
Oncostatin M Signaling Pathway
IL-9 Signaling Pathway
IL-7 Signaling Pathway
Interleukin-3, 5 and GM-CSF signaling
References
Ref 536279Immunotherapy for De Novo renal transplantation: what's in the pipeline? Drugs. 2006;66(13):1665-84.
Ref 536279Immunotherapy for De Novo renal transplantation: what's in the pipeline? Drugs. 2006;66(13):1665-84.

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