Drug General Information
Drug ID	D0P1YO
Former ID	DIB008436
Drug Name	MOL-218
Synonyms	MOL-218; MOL-254; MOL-268; MOL-294; NFkB inhibitors, Molecumetics
Indication	Asthma [ICD10:J45]		Terminated	[546667]
Company	Molecumetics Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	n1(c(=O)n2n(c1=O)[C@@H](C=C[C@@H]2C(C#CC(=O)OC)O)C)c1cc<br />ccc1
CAS Number	CAS 203455-50-9
Target and Pathway
Target(s)	Nuclear factor NF-kappa-B	Target Info	Inhibitor	[527469]
KEGG Pathway	MAPK signaling pathway
	NF-kappa B signaling pathway
	Osteoclast differentiation
	Legionellosis
	HTLV-I infection
	Epstein-Barr virus infection
	Pathways in cancer
	Viral carcinogenesis
NetPath Pathway	IL5 Signaling Pathway
PANTHER Pathway	Apoptosis signaling pathway
	B cell activation
	Inflammation mediated by chemokine and cytokine signaling pathway
	T cell activation
	Toll receptor signaling pathway
Pathway Interaction Database	IL12-mediated signaling events
	Alternative NF-kappaB pathway
PathWhiz Pathway	Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
	Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome	RIP-mediated NFkB activation via ZBP1
	DEx/H-box helicases activate type I IFN and inflammatory cytokines production
	TAK1 activates NFkB by phosphorylation and activation of IKKs complex
	Interleukin-1 processing
	IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
	IkBA variant leads to EDA-ID
	Dectin-1 mediated noncanonical NF-kB signaling
	NIK-->noncanonical NF-kB signaling
	TRAF6 mediated NF-kB activation
WikiPathways	Toll-like receptor signaling pathway
	DNA Damage Response (only ATM dependent)
	SIDS Susceptibility Pathways
	Nuclear Receptors Meta-Pathway
	Cytosolic sensors of pathogen-associated DNA
	TAK1 activates NFkB by phosphorylation and activation of IKKs complex
	EBV LMP1 signaling
	TNF alpha Signaling Pathway
	TSLP Signaling Pathway
	Neural Crest Differentiation
	TWEAK Signaling Pathway
	RANKL/RANK Signaling Pathway
	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
	Interleukin-1 processing
	Folate Metabolism
	Vitamin B12 Metabolism
	Selenium Micronutrient Network
	Regulation of toll-like receptor signaling pathway
References
Ref 546667	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009549)
Ref 527469	NF-kappaB plays a major role during the systemic and local acute inflammatory response following intestinal reperfusion injury. Br J Pharmacol. 2005 May;145(2):246-54.

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