Drug General Information
Drug ID	D0P4KF
Former ID	DNC005068
Drug Name	2-(4-tert-Butyl-phenyl)-4,5-dihydro-1H-imidazole
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527180]
Structure		Download 2D MOL 3D MOL
Formula	C13H18N2
Canonical SMILES	CC(C)(C)C1=CC=C(C=C1)C2=NCCN2
InChI	1S/C13H18N2/c1-13(2,3)11-6-4-10(5-7-11)12-14-8-9-15-12/h4-7H,8-9H2,1-3H3,(H,14,15)
InChIKey	JRUYKUSXUFPDNO-UHFFFAOYSA-N
PubChem Compound ID	44269078
Target and Pathway
Target(s)	Alpha-1A adrenergic receptor	Target Info	Inhibitor	[527180]
	5-hydroxytryptamine 1D receptor	Target Info	Inhibitor	[527180]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	AMPK signaling pathway
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Salivary secretionhsa04024:cAMP signaling pathway
	Serotonergic synapse
PANTHER Pathway	Alpha adrenergic receptor signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathway
Reactome	Adrenoceptors
	G alpha (q) signalling events
	G alpha (12/13) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (i) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Endothelin Pathways
	GPCR ligand binding
	GPCR downstream signaling
	AMPK SignalingWP722:Serotonin HTR1 Group and FOS Pathway
References
Ref 527180	Bioorg Med Chem Lett. 2004 Sep 20;14(18):4697-9.2-(Anilino)imidazolines and 2-(benzyl)imidazoline derivatives as h5-HT1D serotonin receptor ligands.
Ref 527180	Bioorg Med Chem Lett. 2004 Sep 20;14(18):4697-9.2-(Anilino)imidazolines and 2-(benzyl)imidazoline derivatives as h5-HT1D serotonin receptor ligands.

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