TTD | Drug: D0P6IV

Drug General Information
Drug ID	D0P6IV
Former ID	DIB018121
Drug Name	[11C]AZ10419369
Synonyms	[11C]AZ10419369 (PET ligand)
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540548]
Structure		Download 2D MOL
Formula	C26H30N4O4
InChI	InChI=1S/C26H30N4O4/c1-18-3-8-21(30-11-9-28(2)10-12-30)25-24(18)22(31)17-23(34-25)26(32)27-19-4-6-20(7-5-19)29-13-15-33-16-14-29/h3-8,17H,9-16H2,1-2H3,(H,27,32)/i2-1
InChIKey	JKPWOPNZKYPRPZ-JVVVGQRLSA-N
PubChem Compound ID	42608431
PubChem Substance ID	74382771, 86448403, 178100755
Target and Pathway
Target(s)	5-hydroxytryptamine 1B receptor	Target Info	Agonist	[530875]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PANTHER Pathway	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
Reactome	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 540548	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3926).
Ref 530875	Quantitative analysis of [11C]AZ10419369 binding to 5-HT1B receptors in human brain. J Cereb Blood Flow Metab. 2011 Jan;31(1):113-23.

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Drug Information