Drug Information

Drug General Information
Drug ID
D0P7FK
Former ID
DNC009527
Drug Name
2-Amino-4-furan-2-yl-6-phenyl-nicotinonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529602]
Structure
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2D MOL

3D MOL
Formula
C16H11N3O
Canonical SMILES
C1=CC=C(C=C1)C2=NC(=C(C(=C2)C3=CC=CO3)C#N)N
InChI
1S/C16H11N3O/c17-10-13-12(15-7-4-8-20-15)9-14(19-16(13)18)11-5-2-1-3-6-11/h1-9H,(H2,18,19)
InChIKey
UPNSGUUFOFSFEZ-UHFFFAOYSA-N
PubChem Compound ID
743242
Target and Pathway
Target(s) Adenosine A2b receptor Target Info Inhibitor [529602]
Adenosine A2a receptor Target Info Inhibitor [529602]
Adenosine A1 receptor Target Info Inhibitor [529602]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Alcoholismhsa04015:Rap1 signaling pathway
cAMP signaling pathway
Parkinson's disease
Alcoholismhsa04022:cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Morphine addiction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Pathway Interaction Database C-MYB transcription factor networkhif2pathway:HIF-2-alpha transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolismR-HSA-187024:NGF-independant TRKA activation
Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP80:Nucleotide GPCRs
Monoamine Transport
NGF signalling via TRKA from the plasma membrane
GPCR downstream signaling
GPCRs, OtherWP80:Nucleotide GPCRs
References
Ref 529602J Med Chem. 2008 Aug 14;51(15):4449-55. Epub 2008 Jul 19.2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists.
Ref 529602J Med Chem. 2008 Aug 14;51(15):4449-55. Epub 2008 Jul 19.2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists.

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