Drug Information

Drug General Information
Drug ID
D0P7RI
Former ID
DIB018639
Drug Name
5BrUTP
Synonyms
5-bromouridine triphosphate; bromouridine 5'-triphosphate; 5-bromo-UTP
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539083]
Structure
Download
2D MOL
Formula
C9H14BrN2O15P3
InChI
InChI=1S/C9H14BrN2O15P3/c10-3-1-12(9(16)11-7(3)15)8-6(14)5(13)4(25-8)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h1,4-6,8,13-14H,2H2,(H,20,21)(H,22,23)(H,11,15,16)(H2,17,18,19)/t4-,5-,6-,8-/m1/s1
InChIKey
IWFHOSULCAJGRM-UAKXSSHOSA-N
PubChem Compound ID
9872620
PubChem Substance ID
14837595, 24162857, 45294877, 79387115, 103502132, 104079856, 124361444, 128229348, 135651412, 226926141, 241074951
Target and Pathway
Target(s) P2Y purinoceptor 2 Target Info Agonist [534088]
P2Y purinoceptor 6 Target Info Agonist [534141]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channelshsa04080:Neuroactive ligand-receptor interaction
NetPath Pathway IL5 Signaling Pathway
Reactome G alpha (q) signalling events
P2Y receptors
Surfactant metabolismR-HSA-416476:G alpha (q) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP80:Nucleotide GPCRs
GPCR downstream signaling
References
Ref 539083(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1731).
Ref 534088Pharmacological selectivity of the cloned human P2U-purinoceptor: potent activation by diadenosine tetraphosphate. Br J Pharmacol. 1995 Sep;116(1):1619-27.
Ref 534141Cloning, functional expression and tissue distribution of the human P2Y6 receptor. Biochem Biophys Res Commun. 1996 May 15;222(2):303-8.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.