Drug General Information
Drug ID	D0PN6Z
Former ID	DIB020187
Drug Name	L-AP4
Synonyms	L-2-amino-4-phosphonobutiric acid; L-AP4; S-2-amino-4-phosphonobutyrate
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538887]
Structure		Download 2D MOL 3D MOL
Formula	C4H10NO5P
InChI	InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
InChIKey	DDOQBQRIEWHWBT-VKHMYHEASA-N
PubChem Compound ID	179394
PubChem Substance ID	3153190, 4252812, 7978716, 10259084, 11113375, 11457587, 11459535, 14818549, 24891296, 26651777, 26758214, 33502534, 49896033, 50104307, 57395670, 78666740, 81093357, 90458771, 103205265, 103920819, 104429542, 117682323, 124635408, 124877291, 124877292, 127719431, 132522189, 134345882, 135158089, 135650507, 135651136, 140341569, 162093643, 163688614, 228129920, 241181546
Target and Pathway
Target(s)	Metabotropic glutamate receptor 4	Target Info	Agonist	[525456]
	mGlu6 receptor	Target Info	Agonist	[534382]
	Metabotropic glutamate receptor 8	Target Info	Agonist	[525476]
	Metabotropic glutamate receptor 7	Target Info	Agonist	[525945]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Glutamatergic synapse
	Taste transductionhsa04080:Neuroactive ligand-receptor interaction
	Glutamatergic synapsehsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
Reactome	G alpha (i) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-418594:G alpha (i) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	GPCRs, Class C Metabotropic glutamate, pheromone
	GPCR ligand binding
	GPCR downstream signalingWP501:GPCRs, Class C Metabotropic glutamate, pheromone
	GPCR downstream signaling
	GPCRs, OtherWP501:GPCRs, Class C Metabotropic glutamate, pheromone
References
Ref 538887	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1410).
Ref 525456	Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor. J Biol Chem. 1999 Apr 9;274(15):10008-13.
Ref 525476	Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. Brain Res Mol Brain Res. 1999 Apr 20;67(2):201-10.
Ref 525945	Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54.
Ref 534382	Cloning, distribution and functional expression of the human mGlu6 metabotropic glutamate receptor. Neuropharmacology. 1997 Feb;36(2):145-52.

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