Drug Information
Drug General Information | |||||
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Drug ID |
D0PW7B
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Former ID |
DIB019737
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Drug Name |
DIDS
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Synonyms |
4,4'-diisothiocyanostilbene-2,2'-disulphonic acid
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [467515] | ||
Structure |
Download2D MOL |
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Formula |
C16H10N2O6S4
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InChI |
InChI=1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)
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InChIKey |
YSCNMFDFYJUPEF-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | ClC-Kb | Target Info | Blocker (channel blocker) | [543924] | |
ClC-7 | Target Info | Blocker (channel blocker) | [531154] | ||
ClC-Ka | Target Info | Blocker (channel blocker) | [543923] | ||
ClC-6 | Target Info | Blocker (channel blocker) | [543926] | ||
VRAC | Target Info | Blocker (channel blocker) | [543931] | ||
calcium activated channel anoctamin 1 | Target Info | Blocker (channel blocker) | [543928] | ||
Maxi Cl- | Target Info | Blocker (channel blocker) | [531154] | ||
Reactome | Stimuli-sensing channels | ||||
References | |||||
Ref 531154 | The G215R mutation in the Cl-/H+-antiporter ClC-7 found in ADO II osteopetrosis does not abolish function but causes a severe trafficking defect. PLoS One. 2010 Sep 7;5(9):e12585. | ||||
Ref 543923 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 700). | ||||
Ref 543924 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 701). | ||||
Ref 543926 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 705). | ||||
Ref 543928 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 708). | ||||
Ref 543931 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 710). |
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