Drug Information

Drug General Information
Drug ID
D0Q1BT
Former ID
DAP001117
Drug Name
Clidinium
Synonyms
Librax (TN); N-Methyl quinuclidinyl benzilate; Benzilic acid, ester with 3-hydroxy-1-methylquinuclidinium; Quinuclidinium, 3-hydroxy-1-methyl-, benzilate (ester); (1-methyl-1-azoniabicyclo[2.2.2]octan-3-yl) 2-hydroxy-2,2-diphenylacetate; 3-Hydroxy-1-methylquinuclidinium benzilate (ester); 3-hydroxy-1-methylquinuclidinium benzilate ester; 3-{[hydroxy(diphenyl)acetyl]oxy}-1-methyl-1-azoniabicyclo[2.2.2]octane
Drug Type
Small molecular drug
Indication Abdominal stomach pain; Irritable bowel syndrome [ICD9: 789.0, 338, 780, 564.1, 787.91; ICD10:R10, G89, R52, A09, K58, K59.1] Approved [540498], [550751], [551871]
Therapeutic Class
Analgesics
Company
Hoffmann La Roche Inc
Structure
Download
2D MOL

3D MOL
Formula
C22H26NO3+
InChI
InChI=1S/C22H26NO3/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-11,17,20,25H,12-16H2,1H3/q+1
InChIKey
HOOSGZJRQIVJSZ-UHFFFAOYSA-N
CAS Number
CAS 7020-55-5
PubChem Compound ID
2784
PubChem Substance ID
10055, 5527706, 5864563, 7978960, 8151796, 10544421, 11335873, 11361112, 11363050, 11365612, 11368174, 11371367, 11373981, 11376336, 11462084, 11466850, 11467970, 11483904, 11486400, 11487940, 11490170, 11492106, 11493970, 29221939, 46507814, 47291148, 47365199, 47365200, 47589012, 47662296, 48259241, 48334503, 49698978, 50807214, 57321458, 85209725, 96079550, 103188114, 103952426, 104301601, 124883402, 128485066, 134222992, 134338362, 135077135, 135650108, 135651180, 135950079, 137260982, 141696484
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M1 Target Info Antagonist [537371]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 540498(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 366).
Ref 550751Drug information of Clidinium, 2008. eduDrugs.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537371Accidental acute clidinium toxicity. Emerg Med J. 2009 Jun;26(6):460.

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