Drug Information

Drug General Information
Drug ID
D0Q1ER
Former ID
DNC011782
Drug Name
CGS-12066B
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Terminated [538669], [546046]
Structure
Download
2D MOL

3D MOL
Formula
C17H17F3N4
InChI
InChI=1S/C17H17F3N4/c1-22-7-9-23(10-8-22)16-15-3-2-6-24(15)14-5-4-12(17(18,19)20)11-13(14)21-16/h2-6,11H,7-10H2,1H3
InChIKey
LXFHSCDLMBZYKY-UHFFFAOYSA-N
PubChem Compound ID
2689
PubChem Substance ID
5658900, 8151746, 11110877, 11113615, 14851157, 24263004, 26751815, 29221846, 47291321, 47291322, 47662508, 50070771, 50104508, 76144594, 85209444, 85787308, 90341822, 103197449, 103927403, 104301319, 124749628, 124879474, 124879475, 124879476, 126407429, 128554479, 131342071, 134348987, 135610867, 135650081, 162220815, 162958006, 179149568, 227848535, 250105533
Target and Pathway
Target(s) 5-hydroxytryptamine 1B receptor Target Info Modulator
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 538669(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 109).
Ref 546046Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006033)

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