Drug General Information
Drug ID
D0Q1PR
Former ID
DAP000105
Drug Name
Atracurium
Synonyms
Atracurium Dibesylate; Tracrium (TN); 2,2'-{pentane-1,5-diylbis[oxy(3-oxopropane-3,1-diyl)]}bis[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium]; 5-[3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl 3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate
Drug Type
Small molecular drug
Indication General anesthesia [ICD9: 338; ICD10:R20.0] Approved [537821]
Therapeutic Class
Neuromuscular Nondepolarizing Agents
Company
Burroughs Wellcome Co
Structure
Download
2D MOL

3D MOL

Formula
C53H72N2O12+2
Canonical SMILES
C[N+]1(CCC2=CC(=C(C=C2C1CC3=CC(=C(C=C3)OC)OC)OC)OC)CCC(<br />=O)OCCCCCOC(=O)CC[N+]4(CCC5=CC(=C(C=C5C4CC6=CC(=C(C=C6)<br />OC)OC)OC)OC)C
InChI
1S/C53H72N2O12/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(38)42(54)28-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11-13-27-67-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39)43(55)29-37-15-17-45(59-4)47(31-37)61-6/h14-17,30-35,42-43H,11-13,18-29H2,1-10H3/q+2
InChIKey
YXSLJKQTIDHPOT-UHFFFAOYSA-N
CAS Number
CAS 64228-79-1
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
M03AC04
SuperDrug CAS ID
cas=064228791
Target and Pathway
Target(s) Nicotinic acetylcholine receptor Target Info Antagonist [535185], [536169], [537286]
References
Ref 537821A preliminary assessment of atracurium, a new competitive neuromuscular blocking agent. Acta Anaesthesiol Scand. 1981 Feb;25(1):67-9.
Ref 535185Blockade and activation of the human neuronal nicotinic acetylcholine receptors by atracurium and laudanosine. Anesthesiology. 2001 Apr;94(4):643-51.
Ref 536169Neuromuscular block. Br J Pharmacol. 2006 Jan;147 Suppl 1:S277-86.
Ref 537286Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52.

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