| Drug General Information |
| Drug ID |
D0Q4LX
|
| Former ID |
DNC010771
|
| Drug Name |
N-(2-amino-5-(benzofuran-2-yl)phenyl)benzamide
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C21H16N2O2
|
| Canonical SMILES |
C1=CC=C(C=C1)C(=O)NC2=C(C=CC(=C2)C3=CC4=CC=CC=C4O3)N
|
| InChI |
1S/C21H16N2O2/c22-17-11-10-16(20-13-15-8-4-5-9-19(15)25-20)12-18(17)23-21(24)14-6-2-1-3-7-14/h1-13H,22H2,(H,23,24)
|
| InChIKey |
ABLQYLIPCDUOQX-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Histone deacetylase 2 |
Target Info |
Inhibitor |
[1]
|
|---|
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KEGG Pathway
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Cell cycle
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Notch signaling pathway
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Thyroid hormone signaling pathway
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Huntington's disease
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Alcoholism
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Epstein-Barr virus infection
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Pathways in cancer
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Transcriptional misregulation in cancer
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Viral carcinogenesis
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Chronic myeloid leukemia
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Wnt signaling pathway
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Pathway Interaction Database
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Regulation of nuclear SMAD2/3 signaling
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Signaling events mediated by HDAC Class I
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Regulation of Telomerase
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Glucocorticoid receptor regulatory network
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Direct p53 effectors
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Hedgehog signaling events mediated by Gli proteins
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Regulation of nuclear beta catenin signaling and target gene transcription
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Reactome
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p75NTR negatively regulates cell cycle via SC1
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NOTCH1 Intracellular Domain Regulates Transcription
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Constitutive Signaling by NOTCH1 PEST Domain Mutants
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Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
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HDACs deacetylate histones
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NoRC negatively regulates rRNA expression
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RNA Polymerase I Transcription Initiation
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Factors involved in megakaryocyte development and platelet production
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WikiPathways
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Notch Signaling Pathway
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Notch Signaling Pathway
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Neural Crest Differentiation
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Signalling by NGF
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RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
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Factors involved in megakaryocyte development and platelet production
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Cell Cycle
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| References |
| REF 1 | Bioorg Med Chem Lett. 2010 May 15;20(10):3142-5. Epub 2010 Mar 30.Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. |
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