| Drug General Information |
| Drug ID |
D0Q7TO
|
| Former ID |
DIB019953
|
| Drug Name |
K00244
|
| Synonyms |
K00244
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C18H15N5
|
| InChI |
InChI=1S/C18H15N5/c1-12-11-16(23-22-12)20-18-14-9-5-6-10-15(14)19-17(21-18)13-7-3-2-4-8-13/h2-11H,1H3,(H2,19,20,21,22,23)
|
| InChIKey |
JYCUVOXSZBECAY-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
10318996, 11618429, 14845469, 16291188, 26716740, 26758808, 43014032, 51258861, 53800751, 99302736, 99444925, 103441262, 104048292, 114518104, 124659180, 137245136, 137275057, 140243665, 160969491, 162851471, 163688035, 178102599, 180372395, 204371601, 208264967, 223443870, 226781412, 241081272, 245750568, 249119794
|
| Target and Pathway |
| Target(s) |
Aurora protein kinase |
Target Info |
Inhibitor |
[1]
|
|---|
| Glycogen synthase kinase-3 beta |
Target Info |
Inhibitor |
[1]
|
| Proto-oncogene tyrosine-protein kinase SRC |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Oocyte meiosishsa04012:ErbB signaling pathway
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Chemokine signaling pathway
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Cell cycle
|
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PI3K-Akt signaling pathway
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Wnt signaling pathway
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Hedgehog signaling pathway
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Axon guidance
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Hippo signaling pathway
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Focal adhesion
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Signaling pathways regulating pluripotency of stem cells
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T cell receptor signaling pathway
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B cell receptor signaling pathway
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Neurotrophin signaling pathway
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Dopaminergic synapse
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Insulin signaling pathway
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Melanogenesis
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Prolactin signaling pathway
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Thyroid hormone signaling pathway
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Non-alcoholic fatty liver disease (NAFLD)
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Alzheimer's disease
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Hepatitis C
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Measles
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Influenza A
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HTLV-I infection
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Epstein-Barr virus infection
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Pathways in cancer
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Colorectal cancer
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Endometrial cancer
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Prostate cancer
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Basal cell carcinomahsa04012:ErbB signaling pathway
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Rap1 signaling pathway
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Endocytosis
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VEGF signaling pathway
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Adherens junction
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Tight junction
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Gap junction
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Platelet activation
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GABAergic synapse
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Inflammatory mediator regulation of TRP channels
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Regulation of actin cytoskeleton
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GnRH signaling pathway
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Estrogen signaling pathway
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Oxytocin signaling pathway
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Bacterial invasion of epithelial cells
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Epithelial cell signaling in Helicobacter pylori infection
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Shigellosis
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Tuberculosis
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Hepatitis B
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Viral carcinogenesis
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Proteoglycans in cancer
|
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NetPath Pathway
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IL2 Signaling Pathway
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PANTHER Pathway
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Alzheimer disease-presenilin pathway
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Angiogenesis
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Cadherin signaling pathway
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Hedgehog signaling pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Insulin/IGF pathway-protein kinase B signaling cascade
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Interleukin signaling pathway
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PDGF signaling pathway
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PI3 kinase pathway
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Wnt signaling pathway
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Ras Pathway
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CCKR signaling map STP00005:Angiogenesis
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Integrin signalling pathway
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Parkinson disease
|
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CCKR signaling map ST
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Pathway Interaction Database
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LPA receptor mediated events
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Degradation of beta catenin
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Reelin signaling pathway
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Presenilin action in Notch and Wnt signaling
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Integrin-linked kinase signaling
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CDC42 signaling events
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LKB1 signaling events
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Canonical Wnt signaling pathway
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Glucocorticoid receptor regulatory network
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C-MYC pathway
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Regulation of Androgen receptor activity
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BMP receptor signaling
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Hedgehog signaling events mediated by Gli proteins
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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Validated transcriptional targets of deltaNp63 isoforms
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Aurora A signaling
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Insulin-mediated glucose transport
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Class I PI3K signaling events mediated by Akt
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p53 pathway
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Trk receptor signaling mediated by PI3K and PLC-gammaendothelinpathway:Endothelins
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Signaling events mediated by PRL
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Atypical NF-kappaB pathway
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Glypican 1 network
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Plasma membrane estrogen receptor signaling
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
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Signaling events mediated by PTP1B
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S1P3 pathway
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EPHB forward signaling
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Nectin adhesion pathway
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Regulation of p38-alpha and p38-beta
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Signaling events regulated by Ret tyrosine kinase
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Arf6 signaling events
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Signaling events mediated by TCPTP
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FAS (CD95) signaling pathway
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Thromboxane A2 receptor signaling
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Netrin-mediated signaling events
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Alpha9 beta1 integrin signaling events
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CXCR4-mediated signaling events
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EGF receptor (ErbB1) signaling pathway
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Class I PI3K signaling events
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Posttranslational regulation of adherens junction stability and dissassembly
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E-cadherin signaling in the nascent adherens junction
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amb2 Integrin signaling
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Integrins in angiogenesis
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ErbB1 downstream signaling
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Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
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ErbB2/ErbB3 signaling events
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EPHA forward signaling
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E-cadherin signaling in keratinocytes
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PDGFR-beta signaling pathway
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Nongenotropic Androgen signaling
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Internalization of ErbB1
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CXCR3-mediated signaling events
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Signaling events mediated by VEGFR1 and VEGFR2
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Syndecan-2-mediated signaling events
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Syndecan-3-mediated signaling events
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Ephrin B reverse signaling
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Trk receptor signaling mediated by PI3K and PLC-gamma
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EPHA2 forward signaling
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Alpha-synuclein signaling
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FGF signaling pathway
|
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Alpha4 beta1 integrin signaling events
|
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Signaling events mediated by focal adhesion kinase
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Reactome
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APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
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Separation of Sister Chromatids
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Resolution of Sister Chromatid Cohesion
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RHO GTPases Activate ForminsR-HSA-195253:Degradation of beta-catenin by the destruction complex
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AKT phosphorylates targets in the cytosol
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Regulation of HSF1-mediated heat shock response
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CRMPs in Sema3A signaling
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Disassembly of the destruction complex and recruitment of AXIN to the membrane
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S33 mutants of beta-catenin aren't phosphorylated
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S37 mutants of beta-catenin aren't phosphorylated
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S45 mutants of beta-catenin aren't phosphorylated
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T41 mutants of beta-catenin aren't phosphorylated
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Degradation of GLI2 by the proteasome
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Constitutive Signaling by AKT1 E17K in Cancer
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WikiPathways
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EGF/EGFR Signaling Pathway
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JAK/STAT
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Gastric Cancer Network 1
|
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Integrated Breast Cancer Pathway
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APC/C-mediated degradation of cell cycle proteinsWP710:DNA Damage Response (only ATM dependent)
|
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Senescence and Autophagy in Cancer
|
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Notch Signaling Pathway
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Glycogen Metabolism
|
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Insulin Signaling
|
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Wnt Signaling Pathway
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Wnt Signaling Pathway and Pluripotency
|
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IL-6 signaling pathway
|
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Wnt Signaling Pathway Netpath
|
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Copper homeostasis
|
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Focal Adhesion
|
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Hair Follicle Development: Induction (Part 1 of 3)
|
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Cardiac Hypertrophic Response
|
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Degradation of beta-catenin by the destruction complex
|
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T-Cell Receptor and Co-stimulatory Signaling
|
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Cardiac Progenitor Differentiation
|
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BDNF signaling pathway
|
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Corticotropin-releasing hormone
|
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B Cell Receptor Signaling Pathway
|
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IL17 signaling pathway
|
|
Neural Crest Differentiation
|
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Alzheimers Disease
|
|
IL-7 Signaling Pathway
|
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Regulation of Microtubule Cytoskeleton
|
|
TWEAK Signaling Pathway
|
|
Leptin signaling pathway
|
|
Semaphorin interactions
|
|
Cell Cycle
|
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MicroRNAs in cardiomyocyte hypertrophy
|
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Androgen receptor signaling pathway
|
|
IL-5 Signaling PathwayWP673:ErbB Signaling Pathway
|
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EPO Receptor Signaling
|
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TGF beta Signaling Pathway
|
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Signaling of Hepatocyte Growth Factor Receptor
|
|
Kit receptor signaling pathway
|
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Pregnane X Receptor pathway
|
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Aryl Hydrocarbon Receptor Pathway
|
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IL-3 Signaling Pathway
|
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Nanoparticle-mediated activation of receptor signaling
|
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Polycystic Kidney Disease Pathway
|
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Alpha 6 Beta 4 signaling pathway
|
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Integrated Pancreatic Cancer Pathway
|
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Oncostatin M Signaling Pathway
|
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Interleukin-11 Signaling Pathway
|
|
AGE/RAGE pathway
|
|
Signaling Pathways in Glioblastoma
|
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TSLP Signaling Pathway
|
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Arylhydrocarbon receptor (AhR) signaling pathway
|
|
FSH signaling pathway
|
|
RANKL/RANK Signaling Pathway
|
|
Integrin-mediated Cell Adhesion
|
|
Angiogenesis
|
| References |
| REF 1 | The discovery of the potent aurora inhibitor MK-0457 (VX-680). Bioorg Med Chem Lett. 2009 Jul 1;19(13):3586-92. |
|---|
