Drug Information

Drug General Information
Drug ID
D0Q9JT
Former ID
DAP000424
Drug Name
Metyrapone
Synonyms
MYT; Mepyrapone; Metapirone; Metapyron; Methapyrapone; Methbipyranone; Methopirapone; Methopyrapone; Methopyrinine; Methopyrone; Metirapona; Metopiron; Metopirone; Metopyrone; Metroprione; Metyrapon; Metyraponum; Alliance Brand of Metyrapone; Metyrapone Alliance Brand; Metyrapone Novartis Brand; Novartis Brand of Metyrapone; Su 4885; METOPIRONE (TN); Metirapona [INN-Spanish]; Metopirone (TN); Metyraponum [INN-Latin]; Su-4885; Metyrapone (JP15/USP/INN); Metyrapone [USAN:INN:BAN:JAN]; 1,2-Di-3-pyridyl-2-methyl-1-propanone; 2-Methyl-1,2-bis(3-pyridyl)-1-propanone; 2-Methyl-1,2-di-3-pyridinyl-1-propanone; 2-Methyl-1,2-di-3-pyridyl-1-propanone; 2-methyl-1,2-dipyridin-3-yl-propan-1-one; 2-methyl-1,2-dipyridin-3-ylpropan-1-one
Drug Type
Small molecular drug
Indication Cushing's disease [ICD9: 255; ICD10:E24.0] Approved [468277], [538462]
Therapeutic Class
Antimetabolites
Company
Norvatis Phamaceuticals Corporation
Structure
Download
2D MOL

3D MOL
Formula
C14H14N2O
InChI
InChI=1S/C14H14N2O/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11/h3-10H,1-2H3
InChIKey
FJLBFSROUSIWMA-UHFFFAOYSA-N
CAS Number
CAS 54-36-4
PubChem Compound ID
4174
PubChem Substance ID
9414, 86475, 834067, 866374, 3139656, 4904672, 7847476, 7889107, 7979980, 8152614, 10526331, 11112126, 11466932, 11468052, 11486683, 14749227, 24351138, 24888424, 26697184, 26709953, 26755473, 29223280, 46504862, 47193698, 47589141, 48110604, 48185138, 48334651, 48416273, 49699202, 50024064, 50647167, 53789558, 56320925, 56323421, 57322178, 57394052, 85787390, 92125714, 92308195, 93167100, 103243148, 103914631, 103937534, 104169960, 104305644, 117362532, 118810074, 121362605, 121363385
ChEBI ID
ChEBI:44241
SuperDrug ATC ID
V04CD01
SuperDrug CAS ID
cas=000054364
Target and Pathway
Target(s) Cytochrome P450 11B1, mitochondrial Target Info Inhibitor [535383]
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Glucocorticoid biosynthesis
Mineralocorticoid biosynthesis
KEGG Pathway Steroid hormone biosynthesis
Metabolic pathways
PathWhiz Pathway Steroidogenesis
Reactome Glucocorticoid biosynthesis
Endogenous sterols
WikiPathways Metapathway biotransformation
Oxidation by Cytochrome P450
Metabolism of steroid hormones and vitamin D
Corticotropin-releasing hormone
References
Ref 468277(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5224).
Ref 538462FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 012911.
Ref 535383Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line. Toxicol In Vitro. 2002 Apr;16(2):113-21.

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